Vip/pacap Peptides Offered by Bachem

Vasoactive intestinal polypeptide (VIP) and pituitary adenyl-ate cyclase activating polypeptide (PACAP) belong to a family of regulatory peptides which are widely expressed in the body. Their widespread distribution is correlated with their involvement in a large variety of biological activities. Both peptides display a remarkable amino acid sequence homology. They exert their biological effects through specific membrane receptors , belonging to the superfamily of G-protein-coupled receptors (GPCRs), named PACAP/VIP-receptors, whose signaling mechanism involves the activation of adenylate cyclase and phospholipase C cascades. Since their discovery VIP and PACAP have become the research interest of many laboratories , as reflected by the increasing number of publications related to this subject. In this brochure we present a selection of products for VIP and PACAP research. Introduction Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating poly-peptide (PACAP) belong to the same family of structurally related peptide hormones that also includes secretin, glucagon, growth hormone-releasing factor (GRF), and glucagon-like peptide-1 and-2 (GLP-1, GLP-2). It is assumed that this family of peptides resulted from the duplication of a common ancestral gene, which then diverged extensively.